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The workings and paradoxical effects of antidepressant medication

Schoenmaker, Carina (2019) The workings and paradoxical effects of antidepressant medication. Master's Thesis / Essay, Biomedical Sciences.


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Patients with Major Depressive Disorder are often treated using antidepressant medication such as Selective Serotonin Reuptake Inhibitors or Tricyclic Antidepressants. Some studies have been published that show that these antidepressants may deteriorate the state of the depression and even cause suicidal ideation or action. This literature review gives an overview of the aetiology of MDD, as far as this has been uncovered. A short overview of medications and alternative treatments available is described. This raises the question which mechanics are behind the paradoxical workings of antidepressant medication. The main hypothesis says that when serotonergic pathways are altered due to administration of elective Serotonin Reuptake Inhibitors or Tricyclic Antidepressants, not only serotonin but also glutamate levels are affected. An increase of serotonin, causing the patient to be more activated, and a decrease of glutamate, resulting in a decrease in mood. Another hypothesis discusses the difference between individuals in vulnerability to depression and antidepressants, causing an unexpected effect in response to medication in a patient.

Item Type: Thesis (Master's Thesis / Essay)
Supervisor name: Eisel, U.L.M.
Degree programme: Biomedical Sciences
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 25 Sep 2019
Last Modified: 26 Sep 2019 11:05

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