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Twin Discordance Provides New Insights Into Multiple Sclerosis Pathogenesis

Winkel, Simon (2019) Twin Discordance Provides New Insights Into Multiple Sclerosis Pathogenesis. Master's Thesis / Essay, Biomedical Sciences.

Final-191022 Essay Simon Winkel.pdf

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This review used four different classical twin design studies to provide insight into immunopathogenesis of multiple sclerosis (MS), into the origin of MS and into the initial phase prior to the exacerbation of MS. MS is the most common neurodegenerative disease in young adults. MS onset is typically between 20 and 40 years of age and is characterized by reversible episodes of neurological dysfunction. Eventually, progression of MS results in irreversible neurological dysfunction called secondary progressive MS. The prevalence of MS is highly variable; women and individuals from European origin are predominantly affected by MS. Whether this is due to genetics, environmental effects, or interplay between both is not completely understood. Vitamin D deficiency together with the environmental effect of residence in high-latitude regions have been linked to an increased prevalence of MS. Especially the HLA-DRB1*15:01 haplotype together with Epstein–Barr Virus (EBV) infection is highly associated with MS pathogenesis. Many different factors possibly contributing to MS pathogenesis have been studied in the past decade, yet the origin of MS is still not completely understood. To increase understanding how MS pathogenesis is induced, heritable and environmental risk factors will be discussed in combination with monozygotic (MZ) twins discordant for MS.

Item Type: Thesis (Master's Thesis / Essay)
Supervisor name: Laman, J.D.
Degree programme: Biomedical Sciences
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 24 Oct 2019
Last Modified: 28 Oct 2019 10:44

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