van Wijngaarden, Anne (2019) Cell Lineage Tracing in the Haematopoietic System. Master's Thesis / Essay, Biomedical Sciences.
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Abstract
The classical model of haematopoiesis has already been proposed in the sixties and consists of a stepwise differentiation into the mature myeloid and lymphoid cells. However, due to recent developments in the field of lineage tracing technologies, other models of haematopoiesis have been proposed. Current cell tracing methods and their contribution include barcoding, CRISPR/Cas9 based technologies and sequencing methods. These methods, their advantages and limitations are described as well as what they have taught us in the haematopoietic system. It is proposed that contrary to a stepwise differentiation, that haematopoiesis likely occurs as a continuum out of a heterogeneous pool of HSCs instead of a stepwise differentiation process. Furthermore, it is discussed what method will is the most optimal to fully untangle human haematopoiesis and what future applications and innovations might be expected.
| Item Type: | Thesis (Master's Thesis / Essay) |
|---|---|
| Supervisor name: | Haan, G. de and Schuringa, J.J. |
| Degree programme: | Biomedical Sciences |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 03 Dec 2019 |
| Last Modified: | 04 Dec 2019 13:10 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/21278 |
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