In vitro construction of epidermal growth factor receptor kinase domain

Zietse, Michiel (2019) In vitro construction of epidermal growth factor receptor kinase domain. Bachelor's Thesis, Pharmacy.

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Abstract

Mutations of the kinase domain of epidermal growth factor receptor (EGFR) are a common cause of non-small cell lung cancer (NSCLC). Mutations lead to overactivity of EGFR resulting in increased proliferation, cell growth, cell survival and protein synthesis. Three generations of tyrosine kinase inhibitors (TKIs) have been developed, targeting various EGFR mutations. However, many mutational subtypes have been detected. TKI effectiveness is highly specific in regard to the mutation. Moreover, resistance to TKI is common, increasing the complexity of treatment selection. Optimal treatment for many rare mutations is yet to be determined. Therefore, optimal selection of TKIs could be achieved by the development of recombinant active EGFR tyrosine kinases in E. Coli. Binding of the various EMA approved TKIs to the mutated EGFR could be measured.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Groves, M.R. and Vilacha Madeira R Santos, J.F.
Degree programme:	Pharmacy
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	08 Jan 2020 10:14
Last Modified:	08 Jan 2020 10:14
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/21344

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