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Mechanistic Insights Into Regulation of virulence and Diffusible Signal Factor (DSF)-mediated Quorum Sensing in Xanthomonas citri

Venkatesh, Yashika (2019) Mechanistic Insights Into Regulation of virulence and Diffusible Signal Factor (DSF)-mediated Quorum Sensing in Xanthomonas citri. Master's Thesis / Essay, Biomolecular Sciences.

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Abstract

Xanthomonas citri subsp. citri (Xcc) is the etiological agent of a disease called citrus canker that affects almost all types of citrus crops. Xcc virulence factors are produced as a result of infection and they are controlled by a gene cluster rpf (regulation of pathogenicity factor), which encodes components of a cell-cell communication system called Quorum Sensing. Cell-to-cell signals of the Diffusible Signal Factor (DSF) family are cis-2-unsaturated fatty acids of differing chain length and branching pattern. The expression of virulence factors in plant pathogenic Xanthomonas spp. are regulated and coordinated by the system, diffusible signal factor (DSF)-mediated quorum sensing (QS). This regulation involves functions such as antibiotic tolerance, biofilm formation and the production of virulence factors. The virulence is influenced and regulated by certain factors such as adhesins, proteic structures for anchoring and protein secretion systems which involve the production of toxins and other substances. Perturbation of the DSF mediated QS can significantly reduce the severity of the bacterial disease and offers the possibility to control the infection. In this review, I have provided insights into the DSF-mediated QS regulation during plant-pathogen interactions in Xcc, the virulence factors affected by QS hampering, the main secretion systems that are active in virulence and their effect on the symptomatology of citrus canker.

Item Type: Thesis (Master's Thesis / Essay)
Supervisor name: Scheffers, D.J.
Degree programme: Biomolecular Sciences
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 14 Jan 2020 10:07
Last Modified: 14 Jan 2020 10:07
URI: https://fse.studenttheses.ub.rug.nl/id/eprint/21401

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