Wedman, Jouke (2019) Unconventional uses of CRISPR/Cas. Master's Thesis / Essay, Biomedical Sciences.
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Abstract
CRISPR/Cas is an antiviral immune system in prokaryotes that has been repurposed to serve as a genetic engineering tool. Conventional use of this repurposed CRISPR/Cas system aims to induce physiological changes to cells by altering the way cells are able to interact with their genome. However, CRISPR/Cas has other applications in biomedical sciences which are perhaps overshadowed by the vast amounts of research that use CRISPR/Cas in a conventional manner. Hence, this thesis aims to review unconventional uses of CRISPR/Cas. Seven different uses are described: chromatin pull-down assays, genome imaging, programmable genome organization, RNA-tracking, recording, and storage of information, molecular diagnostics, and smart materials. Concluded is that while these CRISPR/Cas-based tools are not unique in their purpose, they have many advantages compared to their traditional counterparts aimed to fulfill the same purpose.
| Item Type: | Thesis (Master's Thesis / Essay) |
|---|---|
| Supervisor name: | Foijer, F. and Hong, C. |
| Degree programme: | Biomedical Sciences |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 28 Jan 2020 08:39 |
| Last Modified: | 28 Jan 2020 08:39 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/21458 |
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