The neurobiological substrate of Misophonia - Recent Insights

Hukema, Fleur (2020) The neurobiological substrate of Misophonia - Recent Insights. Bachelor's Thesis, Biology.

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Abstract

Misophonia is a relatively new neurobehavioral condition in which specific human sounds (so-called trigger sounds) evoke a negative emotional response (primarily anger or disgust), together with an autonomic reaction. In the past ten years, the interest in misophonia and defining its underlying mechanism accelerated, as it is yet to be determined. So far, researchers have found an increased reactivity of the salience network, especially the anterior insular cortex (AIC) and the right anterior cingulate complex (ACC), upon exposure to a trigger sound, leading to hyper-focus on the sound. Other studies have shown hyperactivation of the amygdala and the hypothalamus, which both stand in close connectivity with the salience network, and are involved in pathways controlling aggression and fear, and the consolidating memories, leading to an association between the trigger sound and the immediate negative emotional response, followed by general arousal. So far, no medication has been approved yet to treat misophonic patients. However, therapy programs have shown to be beneficial for misophonic patients.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Zee, E.A. van der
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	10 Feb 2020 12:36
Last Modified:	10 Feb 2020 12:36
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/21513

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