Gijsbers, Gertruda Maria (2020) Determination of Antimicrobial Activity of Alkyloxy Benzene-1,2-diols. Research Project, Science Education and Communication.
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Abstract
Asiatic citrus canker is a disease in orange trees, caused by the bacterium Xanthomonas citri. Earlier research has showed the antimicrobial effects of alkyl gallates and alkyl dihydroxybenzoates against this bacterium. Alkyloxy benzene-1,2-diols have also shown to be effective. I was interested to know whether these ethers had an antimicrobial effect against other bacterial species as well. Therefore, it was tested whether they had antimicrobial activity against Bacillus subtilis and Escherichia coli. It was found that the ethers with between 4 and 9 carbons in their carbon tail had an antimicrobial effect on B. subtilis, but not on E. coli. The highest activity was found for the ethers with 6, 7 or 8 carbons in their tail. The results for the Minimal Inhibitory and Minimal Bactericidal Concentration were the same, showing that the ethers are in fact bactericidal. Performance of a LIVE/DEAD assay showed that heptyloxy benzene-1,2-diol permeabilizes the bacterial membrane of B. subtilis.
| Item Type: | Thesis (Research Project) |
|---|---|
| Supervisor name: | Scheffers, D.J. |
| Degree programme: | Science Education and Communication |
| Thesis type: | Research Project |
| Language: | English |
| Date Deposited: | 22 Apr 2020 11:18 |
| Last Modified: | 22 Apr 2020 11:18 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/21795 |
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