The impact of gut dysbiosis on Parkinson’s disease

Schoenmaker, Troy H. (2020) The impact of gut dysbiosis on Parkinson’s disease. Bachelor's Thesis, Life Science and Technology.

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Abstract

Parkinson’s disease (PD) is after Alzheimer the neurodegenerative disorder with the highest prevalence in the world. Around the 2 percent of people aged over 65 years has been diagnosed with PD. This disorder has non-/motor symptoms like tremor, weak muscle strength, altered posture but also mood swings and dementia. Unfortunately, there is still no definitive underlying cause found for the development and/or progress of PD. Hence, a lot of research is done in finding this underlying cause to further understand the development of PD. A recently discovered possible cause of PD can be a dysbiosis in the gut microbiome which means an imbalance of gut microorganisms is present. The gut microbiome is always a highly interested topic because the gastrointestinal tract fulfills a lot of live depending functions such as metabolism, signaling and defensive pathways. The origin of dysbiosis in the gut microbiome can be induced due to the factors: α-Synuclein, short fatty chain acids, lipopolysaccharide, microglia and Toll like receptors. These factors are responsible for Lewy body forming through α-synucleinopathy, a higher permeability of the intestinal layer and more inflammatory responses. In order to cure PD patients a considerable amount of researches are performed through analyzing the effects of the therapeutic strategies as fecal transplantation, pro-, pre- and antibiotics on PD patients. All in all, it can be said that dysbiosis in the gut microbiome plays a role in PD.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Eggen, B.J.L.
Degree programme:	Life Science and Technology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	08 Jun 2020 14:09
Last Modified:	08 Jun 2020 14:09
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/22016

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