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Designing antimicrobial peptides

Bijlsma, Ewout (2020) Designing antimicrobial peptides. Bachelor's Thesis, Life Science and Technology.

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Abstract

Antibiotic resistance is on the rise, with more and more multiple-antibiotic resistant bacteria being found. The classic way of semi synthetic antibiotics has long since yielded a completely new result, so we must find another way. Eukaryote derived and microbe modified antimicrobial peptides are nature’s way to, especially in marine organisms, fight off pathogenic bacteria and remain a healthy host. Some of these are modified to an extent not that is rarely seen in the world, with up to 30 modified amino acids in a peptide only 48 amino acids long. How can we use these types of peptides to further research into novel antimicrobial peptides? Here we find that antimicrobial peptides usually have a length of 30-40 amino acids and a charge of +3 to +4, along with all different kinds of modifications, even some only very recently described for the first time, which may help design anti-microbial peptides.

Item Type: Thesis (Bachelor's Thesis)
Supervisor name: Kuipers, O.P.
Degree programme: Life Science and Technology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 30 Jun 2020 09:54
Last Modified: 30 Jun 2020 09:54
URI: https://fse.studenttheses.ub.rug.nl/id/eprint/22251

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