Karsenberg, Renske (2020) Integrating Darwinian dynamics in prostate cancer treatment: exploring the potential of evolution-based intermittent therapy for metastatic prostate cancer. Bachelor's Thesis, Biology.
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Abstract
Like most other metastatic cancers, metastatic prostate cancer (mPC) remains incurable, despite major advances in the oncology field. Development of drug-resistant tumor cells causes treatment to fail and ultimately leads to tumor progression. This thesis focuses on the potential benefits of incorporating evolutionary theory into treatment of mPC and castrate-resistant mPC variants (mCRPC). A new perspective is investigated, in which long-term tumor control is the central aim, ultimately turning cancer into a chronic disease. Mathematical models have demonstrated the potential of evolution-based intermittent therapy: the administration of appropriately timed on- and off-treatment periods, which takes into consideration evolutionary tumor dynamics. In the clinical field, this has been proven to have significant benefits compared to the current standard of care. These benefits include a delayed time to progression, reduced treatment toxicity and lowered medical expenses. However, as intratumoral dynamics are extremely complex and patient-specific, designing mathematical models and experimental trials remains challenging and further research is needed. Nonetheless, intermittent therapy appears to be a promising approach.
| Item Type: | Thesis (Bachelor's Thesis) |
|---|---|
| Supervisor name: | Elliot, M.G. and Kruyt, F.A.E. |
| Degree programme: | Biology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 20 Jul 2020 09:44 |
| Last Modified: | 20 Jul 2020 09:44 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/22655 |
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