Smits, Eline (2021) cGAS-STING signaling in cancer: good or bad news? Master's Thesis / Essay, Biomedical Sciences.
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Abstract
Genomic instability is one of the hallmarks of cancer, which allows tumor cells to acquire the genetic changes that drive tumor progression. In genomic instable cancer cells, DNA damage repair defects and the consequent cytoplasmic self-DNA have been found to induce the activation of the cGAS-STING pathway, which normally acts as a defence mechanism against pathogens, such as bacteria and viruses. In tumors, cGAS-STING signaling modulates tumor growth, tumor immune evasion and determines treatment outcome. However, the same pathway has recently also been found to play a role in tumor promoting responses and metastasis, which suggests a negative disease outcome. Clearly, these results form a paradox on the role of cGAS-STING signaling in cancer biology. In this essay, the current literature regarding positive and negative effects of cGAS-STING signaling on tumors is reviewed, in which a distinction is made between intracellular effects of STING signaling in cancer cells versus the effect of this pathway on the tumor microenvironment. Furthermore, the potential of cGAS-STING activation in cancer therapy is discussed, based on observations from studies utilizing STING-inducing therapies (e.g. radiotherapy and chemotherapy) and STING agonists.
| Item Type: | Thesis (Master's Thesis / Essay) |
|---|---|
| Supervisor name: | Vugt, M.A.T.M. van |
| Degree programme: | Biomedical Sciences |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 29 Jan 2021 13:59 |
| Last Modified: | 29 Jan 2021 13:59 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/23857 |
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