The Controversy Around Vitamin E Supplementation: A Potential Treatment For Type 2 Diabetes-Related Oxidative Stress?

Schneider, Antonia (2021) The Controversy Around Vitamin E Supplementation: A Potential Treatment For Type 2 Diabetes-Related Oxidative Stress? Master's Thesis / Essay, Biomedical Sciences.

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Abstract

Oxidative stress is a common but serious threat to the metabolism of all aerobic organisms. The essential cellular defence mechanism relies on antioxidants, either synthesized endogenously or supplemented through the diet. Vitamin E constitutes an interesting, exclusively dietary component to counteract oxidative stress and associated pathologies mainly through its antioxidative but also non-antioxidative properties. Despite the prevalence of suboptimal vitamin E levels in the majority of the global population, deficiencies are particularly critical in the context of chronic diseases including but not limited to several neurodegenerative diseases, non-alcoholic fatty liver disease and chronic kidney disease. This led to the idea that vitamin E supplementation might be beneficial to decrease the burden of diseases and improve outcomes. However, clinical trials supplementing vitamin E have provided inconsistent results so far, some even with adverse effects, causing highly controversial debates whether vitamin E supplementation can be implemented to treat redox imbalance. Recent studies indicate that inconsistent outcomes may be due to the respective isoforms administered, mainly α- and γ-tocopherol. This essay elaborates on current evidence on potential of vitamin E supplementation to relieve oxidative stress and improve outcomes related to diabetes type II, considering the dosage and usage of different isoforms.

Item Type:	Thesis (Master's Thesis / Essay)
Supervisor name:	Corpeleijn, E.
Degree programme:	Biomedical Sciences
Thesis type:	Master's Thesis / Essay
Language:	English
Date Deposited:	29 Jan 2021 13:37
Last Modified:	29 Jan 2021 13:37
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/23861

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