Kuppeveld, J.J.L.E.P. van (2021) Tumor derived organoids improve colorectal cancer treatment. Master's Thesis / Essay, Biomedical Sciences.
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Abstract
Colorectal cancer is a deadly disease that is still difficult to treat. Conventional models do not represent the cancer well and treatment response is hard to predict. Recently, research has shown that intestinal stem cells can be maintained indefinitely in culture. This technique made it possible to create patient derived tumor organoids that reflect the disease more accurately than historical models do. These organoids copy key features of the parent tumor and can be used as a new model for colorectal cancer, with other possibilities like measuring patient response to drug treatment. Use of this model can make colorectal cancer treatment more efficient, reducing costs and leading to less patient toxicity. Applications of tumoroids as drug screening models will aid drug development as well, however, more research is needed to solidify their predictive value and culturing methods need to be standardized to standardize clinical use.
| Item Type: | Thesis (Master's Thesis / Essay) |
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| Supervisor name: | Coppes, R.P. |
| Degree programme: | Biomedical Sciences |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 12 Feb 2021 14:42 |
| Last Modified: | 12 Feb 2021 14:42 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/23959 |
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