Exosomes: biogenesis, function and therapeutic potential in cancer

Wal, Ryan, van der (2021) Exosomes: biogenesis, function and therapeutic potential in cancer. Bachelor's Thesis, Biology.

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Abstract

Exosomes are extracellular vesicles that are secreted by eukaryotic cells to mediate cell communication, immune responses and cell signaling for regeneration and cell differentiation. Exosomes are between 30-150nm in size and are transported via body fluids to their recipient cells. Currently, there are two known pathways for exosome production, namely the ESCRT pathway and a ceramide-dependent pathway. Exosomes can be internalized by ligand-receptor interaction, fusion with the outer membrane via lipid raft endocytosis, clathrin-dependent endocytosis and phagocytosis. Tumor-derived exosomes can drive cancer progression by facilitating metastasis, angiogenesis and have immunosuppressive effects. Additionally, tumor-derived exosomes consist of tumor antigens that can be utilized to trigger an anti-tumor immune response. This review provides an overview of the biogenesis, function and therapeutic potential of exosomes to treat human cancer cells.

Item Type:	Thesis (Bachelor's Thesis)
Supervisor name:	Helfrich, W.
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	05 Mar 2021 15:26
Last Modified:	05 Mar 2021 15:26
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/24034

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