Zevenbergen, Gijsje Petronella (2021) Current insight on the biological transmission of traumas to subsequent generations. Bachelor's Thesis, Biology.
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Abstract
Traumatic experiences can have long-term consequences as it increases the risk to develop disorders such as PTSD and depression. Moreover, it has been observed that the effect of traumas does not only impact the individuals that were exposed to the event but can be transmitted to subsequent generations as well. Next to social transmission, epigenetics mechanisms are suggested to be (partly) responsible for the biological transmission. However, the underlying mechanism behind epigenetic inheritance remains to be established. A growing number of studies investigate the transmission of effects via either DNA methylation or altered non-coding RNA levels. The aim of this thesis is to review the emerging literature on evidence of biological inheritance of effects induced by exposure to traumas. There is still no biological explanation for epigenetic inheritance. However, it has been found that an accumulating amount of studies support the hypothesis that there is an association between altered phenotypes and epigenetic modifications which influence gene expression. Further research needs to be conducted to determine inter- and transgenerational transmission of the effects of traumas to subsequent generations in humans. A better insight in biological transmission of traumas is of great importance as it may lead to identification of biomarkers of traumatic stress and to advances in the treatment of even prevention of disorders such as PTSD and depression.
| Item Type: | Thesis (Bachelor's Thesis) |
|---|---|
| Supervisor name: | Verhulst, S. |
| Degree programme: | Biology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 10 May 2021 16:26 |
| Last Modified: | 10 May 2021 16:26 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/24386 |
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