Bosch, Hugo, van den (2021) Approaches to improve chimeric antigen receptor T-cell therapy in solid tumors. Focusing on current CAR models and the tumor microenvironment. Bachelor's Thesis, Biology.
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Abstract
The main positive clinical results of CAR T-cell therapy have come from hematological tumors, spurring FDA approval against certain types of hematological malignancies. Apart from an occasional positive result, CAR-T cell therapy in solid tumors has been rather disappointing. Reasons for this include toxicities, limited tumor-associated antigens and the immunosuppressive and difficult to infiltrate tumor microenvironment (TME). This report focuses on the different designs and adjustments that have been made to CARs and indicate their improvements in relation to their persistence, safety and improved activity. Furthermore, emphasis is put on strategies aimed at improving infiltration and antitumor effects of CAR T-cells in the TME.
| Item Type: | Thesis (Bachelor's Thesis) |
|---|---|
| Supervisor name: | Jong, S. de |
| Degree programme: | Biology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 01 Jul 2021 09:57 |
| Last Modified: | 01 Jul 2021 09:57 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/24824 |
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