Brink, Thomas (2021) Prion-like intracerebral and peripheral transmission of amyloid-β and infectivity of Alzheimer’s disease. Bachelor's Thesis, Life Science and Technology.
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Abstract
Due to the ageing population, the amount of Alzheimer’s disease patients is rapidly increasing. Prion-like properties of one of the main factors in Alzheimer’s, amyloid-β, raised concerns whether it also shared prion-like infectivity. Amyloid-β forms seeds in Alzheimer’s patients which cause misfolding of more amyloid-β and leads to aggregation and senile plaques. These seeds are transferrable through intracerebral, intraperitoneal and intravenous injection of amyloid-β rich brain extracts. They are also transferrable through injections with cadaveric human pituitary glands infected with Creutzfeld-Jakob disease, contaminated neurosurgical equipment and blood transfusions from donors with high amyloid-β levels. When transferred to a new host, these seeds cause amyloid-β deposits in the arteries of the brain and in the brain parenchyma. This leads to cerebral amyloid angiopathy increasing the risk of strokes, but not to the full pathology of Alzheimer’s disease. The most worrying routes of transportation are through neurosurgical equipment and through blood transfusions, since these procedures happen in the medical world. Injection with amyloid-β rich brain extracts or cadaveric human pituitary glands never happen to patients, and are not a risk. The two routes of transmission that do pose a risk are not fully understood, so the full extent of the danger is not known. These routes of transmission require further experimental and epidemiological investigation.
| Item Type: | Thesis (Bachelor's Thesis) |
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| Supervisor name: | Eisel, U.L.M. |
| Degree programme: | Life Science and Technology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 12 Jul 2021 10:00 |
| Last Modified: | 12 Jul 2021 10:00 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/24849 |
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