Mitochondrial Dysfunction and Glutamate Excitotoxicity in Multiple Sclerosis

Nagel, E.A. (2021) Mitochondrial Dysfunction and Glutamate Excitotoxicity in Multiple Sclerosis. Master's Thesis / Essay, Biomedical Sciences.

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Abstract

Multiple sclerosis (MS) is a neurodegenerative disease of the central nervous system, characterized by local inflammation, demyelination and axonal loss. MS has traditionally been viewed as an autoimmune disease, however, anti-inflammatory and immunomodulatory treatments have shown to be beneficial in early stages of the disease, but remain largely ineffective in the more progressive stages of MS. Neurodegeneration in MS may therefore not solely be immune system driven, but may also depend on other neurodegenerative mechanism. Accordingly, recent studies have focussed on immune-independent mechanisms involved in MS pathology such as mitochondrial dysfunction and glutamate excitotoxicity. Although these mechanisms are considered to be immune-independent, they can still be triggered by the immune system. In this review, the contribution of inflammation, mitochondrial dysfunction and glutamate excitotoxicity to MS pathology are discussed, together with possible therapeutic targets for the treatment of the disease.

Item Type:	Thesis (Master's Thesis / Essay)
Supervisor name:	Eisel, U.L.M.
Degree programme:	Biomedical Sciences
Thesis type:	Master's Thesis / Essay
Language:	English
Date Deposited:	05 Jul 2021 12:35
Last Modified:	05 Jul 2021 12:35
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/24924

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