Heida, Hennie (2021) The effect of the tumour microenvironment (TME) on the mesenchymal transition in glioblastoma. Master's Thesis / Essay, Biomedical Sciences.
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Abstract
Glioblastoma multiforme (GBM) is the most frequent and malignant type of primary brain tumour. This tumour is difficult to treat, as a result of its invasive nature and heterogeneity. Because of this heterogeneity, GBM has been classified into different subtypes, of which the mesenchymal subtype is the most aggressive type. Since subtypes can shift to one another, it is important to study the mesenchymal transition. Emerging studies imply the importance of targeting the tumour microenvironment (TME), instead of the glioblastoma cells themselves. Importantly, the TME seems to affect the MES transition. Here, the precise mechanism of this is studied for the TAMs, astrocytes and ECs. The TME affects the MES transition by promoting an anti-inflammatory phenotype, and by using hypoxia in their favour. Additionally, it plays a role in the treatment-induced MES transition. Treatment should focus on shifting the phenotype of tumour cells from anti-inflammatory to proinflammatory, as well as use anti-angiogenic therapy that is adjusted to the hypoxic environment. In addition, the resistance to the TME-targeted therapies should be assessed. Further studies are necessary to also evaluate the effect of the other TME cell types, as well as to investigate the other subtypes in order to ensure effective treatment of the MES transition.
| Item Type: | Thesis (Master's Thesis / Essay) |
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| Supervisor name: | Kruyt, F.A.E. |
| Degree programme: | Biomedical Sciences |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 20 Jul 2021 13:32 |
| Last Modified: | 20 Jul 2021 13:32 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/24965 |
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