Praktiek, Jan (2021) Using Evolution to Acquire a Better Understanding of the Mechanisms that Constitute Antifungal Resistance. Bachelor's Thesis, Life Science and Technology.
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Abstract
Pathogenic fungi are at the cause of global problems of massive proportions. More than a million lives are lost every year due to fungal infections. Additionally, around a third of our agricultural produce is lost to spoilage annually because of fungi. Furthermore, fungal pathogens are also responsible for significant loss of biodiversity in animal- and plant species in the wild. Our antifungal drugs are increasingly failing to combat these infections caused by pathogenic fungi, because of the evolution of resistance. In this essay, the problem of fungal infections, combined with the increasing occurrence of resistance against antifungal drugs, will be elaborated upon. Subsequently, an argument will be made for the widespread implementation of experimental evolution, as a means of elucidating the mechanisms of antifungal resistance. This argument will be made on the basis of the successful use of this technique in the study of antibiotic resistance, which shares several striking similarities to the study of antifungal resistance. The principle of experimental evolution could provide us with the necessary opportunities to unravel the mechanisms that constitute the evolution of antifungal resistance. Thus helping us stay ahead in the arms race against evolution of antifungal resistance in pathogenic fungi.
| Item Type: | Thesis (Bachelor's Thesis) |
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| Supervisor name: | Billerbeck, S.K. |
| Degree programme: | Life Science and Technology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 23 Jul 2021 08:18 |
| Last Modified: | 23 Jul 2021 08:18 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/25407 |
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