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Adipose derived stem cells for regenerative cell therapy in peripheral vascular disease

Both, I.M. (2009) Adipose derived stem cells for regenerative cell therapy in peripheral vascular disease. Bachelor's Thesis, Biology.

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Abstract

Regenerative medicine is the emerging field that requires a reliable source of stem cells in addition to biomaterial scaffolds and cytokine growth factors. Adipose tissue has proven to serve as a source of autologous adult stem cells that can be obtained repeatedly in large quantities under local anaesthesia with a minimum of patient discomfort. Compared with bone marrow-derived mesenchymal stem cells, adipose derived stem cells (ADSC) do have an equal potential to differentiate into cells of a lineage specific required cell. Adult stem cells hold, through unclear mechanism, a great promise for repairn and regenerate tissue in peripheral vascular disease (PVD). In PVD there is an obstruction in large arteries in legs and arms, what cause an ischemic area. Although some clinical experience with stem cell therapy in PVD are promising, it is to early for general use of this technique. Long-term effects of these kinds of therapies still have to be investigated, such as the progressive role of vascular endothelial growth factor in atherosclerosis and the role of ADSC in carcinogenesis. In this paper there is a representation of the use of ADSC as cell therapy in PVD patients. Keywords Regenerative cell therapy, peripheral vascular disease, adipose derived stem cells

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:28
Last Modified: 15 Feb 2018 07:28
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/8532

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