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As Bad As Its Reputation? The Physiological Function of Amyloid Precursor Protein and Amyloid-beta

Meyer, N. (2009) As Bad As Its Reputation? The Physiological Function of Amyloid Precursor Protein and Amyloid-beta. Bachelor's Thesis, Biology.

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Abstract

Alzheimer’s Disease is a common neurodegenerative disorder in which the A protein is thought to play an important causative role. For a long time it was supposed that A only has toxic characteristics and is a waste product of APP (Amyloid Precursor Protein) cleavage, however more and more studies find evidence for possible physiological functions of A. APP seems to play an important role in preventing cells from excitotoxicity in a negative feedback manner. Additionally, if applied in physiological amounts, A improves memory formation. Moreover A is part of the lipid metabolim in which it reduces cholesterol levels. APP is important for cell movement in the developing and adult brain, for example by accelerating wound healing. The AICD (APP intracellular domain) is involved in gene transcription and also seems to be a “cell-death mediator”. These findings call for a reassessment of today’s drugs and drug targets against Alzheimer’s Disease, which mostly focus on inhibiting A production or a fast A removal and could thus have a damaging effect for the patient.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:28
Last Modified: 15 Feb 2018 07:28
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/8538

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