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Function of circadian clocks in peripheral tissues

Riede, S.J. (2009) Function of circadian clocks in peripheral tissues. Bachelor's Thesis, Biology.

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Abstract

In this thesis I will review and reflect the present knowledge on functional aspects of clock genes in the peripheral tissues of the mammalian body. ‘Peripheral’ in this thesis can be interpreted in it’s broadest context; all oscillating tissues outside the suprachiasmatic nuclei (SCN). The SCN are seen as the central, or ‘master’ clock in mammals. It is located in the ventral hypothalamus above the optic chiasm, and consists of a small number of endogenously oscillating cells. Rhythms generated by molecular feedback loops comprising several clock genes and their transcripts. It’s phase (‘time’) can be set by light-input from the photosensitive cells in the retina, but also many other external and internal factors are known to affect this clock in one way or another. In turn the SCN influences a great extent of tissues and body functions, both in the brain and in the rest of the body, by a number of output pathways. The SCN is thought to be essential for the synchronization of the body in the timing of all it’s behavioural and physiological processes. In the last decades several studies have suggested or shown the importance of circadian rhythms in gene expression in tissues outside the SCN, in this thesis referred to as ‘peripheral oscillations’. The goal of this thesis is to map our current knowledge on the functional aspect of these peripheral oscillators. Including by which mechanisms they are influenced, how they interact with other timed processes (synchronization) and how they function in vivo.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:28
Last Modified: 15 Feb 2018 07:28
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/8546

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