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Combinatorial biosynthesis on Polyketide Synthase type I

Minnen, A. (2009) Combinatorial biosynthesis on Polyketide Synthase type I. Bachelor's Thesis, Biology.

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Abstract

Using an antibiotic in the clinic will inevitably lead to resistance of bacteria. Because untreatable bacterial infections will lead to worldwide health problems there is an ongoing need for new antibiotics. Several techniques are available to aid in the development of novel antibacterial compounds. Combinatorial biosynthesis of modular type I Polyketide Synthases (PKSs) is one of these techniques. The main aim of this review is to investigate applied and novel combinatorial approaches. We do this by describing the successes and challenges in combinatorial approaches of the extensively studied erythromycin PKS. We will compare our findings to the less studied tylosin PKS. Furthermore, we will seek novel combinatorial approaches that could be applied to tylosin PKS in order to find novel antibiotic derivatives of tylosin.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:28
Last Modified: 15 Feb 2018 07:28
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/8551

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