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The genomic research of secondary metabolites in fungi

Mourik, P.M. van (2010) The genomic research of secondary metabolites in fungi. Bachelor's Thesis, Biology.

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Abstract

Fungi produce bioactive natural products, known as secondary metabolites. These secondary metabolites are low- molecular weight compounds and often bioactive. Some of these secondary metabolites are used for pharmaceutical purposes, such as human antitumor therapy, antiviral and antifungal drug or as antibiotic. These secondary metabolites are synthesized by polyketide synthases (PKSs) and non-ribosomal polyketide synthetases (NRPSs). The genes that are encoding for these enzymes are clustered together in the genome. Genome sequencing on fungi revealed large numbers of secondary metabolite gene clusters, especially PKS and NRPS. From allot of these predicted PKS and NRPS gene clusters the function or metabolic pathway that these enzymes are involved with, remains unknown. Also the predicated metabolites don’t match always with the number of secondary metabolites that are expressed in the fungus. These genes that are involved in this prediction are called silent or cryptic genes, and are not expressed under standard laboratory conditions. Genomic research gives us the ability to discover why these secondary metabolites are made by fungi, and what the products are that are synthesized by the PKSs and NRPSs. This reports gives a review on the genomic research that already has been done on different PKSs and NRPSs genes that are found in fungus species. It is followed by the genomic research on silent gene clusters in fungi and the discovery of new secondary metabolites.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:30
Last Modified: 15 Feb 2018 07:30
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/9066

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