Zwarts, I. (2010) Which subtype Toll-like receptor is important for the signaling of farm dust? Bachelor's Thesis, Biology.
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Abstract
Background: The incidence of allergic disorders is rapidly increasing, especially in the western countries. This brought a renewed interested in the hygiene hypothesis. Epidemiological studies show an association of microbial exposure and infections with the risk of developing allergic diseases. But these studies give little insight in the molecular mechanism behind the hygiene hypothesis. Objectives: We investigated the role of TLR family members in directing the adaptive immune system to mediated the protective effect of farm dust exposure. Results: There were some conflicting results, in some studies it was suggested that TLR 2 and TLR 4 activation induces Treg and Th17 responses, while other studies showed that they induce pro-allergic cytokines. Conclusions: TLR 2 and TLR 4 are most likely to be involved in mediating the protective effect of farm dust exposure. However, the molecular mechanism is still controversial.
| Item Type: | Thesis (Bachelor's Thesis) |
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| Degree programme: | Biology |
| Thesis type: | Bachelor's Thesis |
| Language: | English |
| Date Deposited: | 15 Feb 2018 07:31 |
| Last Modified: | 15 Feb 2018 07:31 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/9269 |
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