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The CRISPR/Cas system in prokaryotes provides resistance against bacteriophages

Plantinga, R. (2010) The CRISPR/Cas system in prokaryotes provides resistance against bacteriophages. Bachelor's Thesis, Biology.

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Abstract

Bacteriophages are the biggest threat to bacteria, therefore they have developed several defense systems against bacteriophages that interact with one of the phases of bacteriophage replication. Recently a new mechanism was discovered: the CRISPR/Cas system. This system consists of a number of repeats on the chromosome, called clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated genes (cas genes). The CRISPR consist of repeats, interspersed with spacers of nearly the same length which are derived from phage genomes. It has been shown that this system provides resistance against bacteriophages. However, the exact mechanism is still not fully elucidated. The transcription of CRISPR RNAs (crRNAs) and their processing by enzyme complexes encoded by the cas genes are possibly important for providing resistance against bacteriophages. In this thesis the scientific progress on the CRISPR/Cas system is described and finally the possible mechanisms will be discussed.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:44
Last Modified: 15 Feb 2018 07:44
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/9334

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