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Dietary restriction: it's never too late

Kruzycka, J.B. (2010) Dietary restriction: it's never too late. Bachelor's Thesis, Biology.

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Abstract

Dietary restriction (DR), the consumption of less food while avoiding malnutrition, increases lifespan in various invertebrate organisms. In the fruit fly lifespan is extended by decreasing the risk of death. Lifespan can also be extended by slowing the rate of aging. The mechanisms by which lifespan is extended in rodents during DR is uncertain. Experiments on rodents lack sufficient sample sizes to draw distinct conclusions from. By studying death rates from several study using the DR regime in mice I can create a larger sample size. Using the Gompertz model I show that the increase in lifespan in mice results primarily from an acute reduction in the risk of death. The current nutritional status determines the chance of survival and hence DR instigated at any time could still increase lifespan. Because rodents share many biological characteristics with humans, these results can possibly be extrapolated to humans.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:44
Last Modified: 15 Feb 2018 07:44
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/9357

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