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Possible preventive treatments of hypertrophic scar formation

Perton, F. (2010) Possible preventive treatments of hypertrophic scar formation. Bachelor's Thesis, Biology.

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Abstract

Scar formation is a normal outcome of wound healing. However, after trauma, surgical injury and especially in burn wounds, hypertrophic scar formation can occur. This is a process of abnormal wound healing resulting in raised, red scars. Patients with hypertrophic scar formation are presented with itching, pressure, pain and cosmetical concerns. It is believed that hypertrophic scar formation is caused by an exaggerated inflammatory response, stimulating fibroblasts to produce excessive ECM. Abnormal ECM composition and increased ECM production result in hypertrophic scars. Current treatments of HSF are inefficient and variable. However still incomplete, our understanding of the etiology of hypertrophic scar formation has lead to new targets for preventive treatments. In this review, mechanisms in normal wound healing and the altered mechanisms in hypertrophic scar formation are described. Potential targets are summarized and the possibilities of preventive therapies using these targets are discussed.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:44
Last Modified: 15 Feb 2018 07:44
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/9373

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