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Migratory factors influencing the invasive character of GBM

Sigar, E.V. (2010) Migratory factors influencing the invasive character of GBM. Bachelor's Thesis, Biology.

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Abstract

Glioblastoma multiforme (GBM) is one of the most common and lethal brain tumors with a low median survival rate for patients. Due to the aggressive character of GBM, the World Health Organization (WHO) has categorized it as the highest grade brain tumor. The prognosis for GBM patients is poor, due to its invasive character combined with high resistance to treatment. The migration of GBM cells is instigated by hypoxia and is influenced by both paracrine and autocrine factors of wich HIFS and VEGF are the most important, other factors include TGF-β, TWIST, cadherin, integrin, matrix-metalloproteinases and CXCL12. These factors and the tumor cell propagation are both involved in an invasive display. Recently, a small group of GBM cells with stem cell properties have been identified, glioblastoma stem cells (GSCs), which drive tumor formation and have been implicated in resistance to treatment. Current research regarding new treatment is concentrated on inhibiting migration and tumor resistance. The aim of this paper is to identify the most influential factors in inducing migration in GBM, and discuss potential targets to attenuate the invasive nature of GBM.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:44
Last Modified: 15 Feb 2018 07:44
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/9432

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