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The activation of the NLRP3 and NLRP1 inflammasomes provide a new insight in the progression of Alzhemeimer's disease

Boer, P. de (2011) The activation of the NLRP3 and NLRP1 inflammasomes provide a new insight in the progression of Alzhemeimer's disease. Bachelor's Thesis, Biology.

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Abstract

Inflammasomes are intracellular multimeric protein complexes, consisting of an NLR-domain, a caspase recruitment domain and pro-caspase-1. Inflammasomes play a role in the innate immune-system by sensing pathogen associated molecular patterns (PAMPs) and danger associated molecular patterns (DAMPs). This leads to caspase-1 acitivity, which subsequently cleaves pro-IL-1β and pro-IL-18 to the active pro-inflammatory cytokines IL-1β and IL-18. Inflammasomes might be involved in the induction of inflammation associated with progression of Alzheimer’s disease (AD). It seems that the NLRP3 inflammasome is activated in microglia by amyloid-β (Aβ) trough lysosomal damage and that the NLRP1 inflammasome is also activated by Aβ in neurons as a result of K+ efflux. This leads to neuro-inflammation and neuronal cell-death, thereby enhancing the AD pathology. These findings might lead to therapeutic implications aiming for the inhibition of inflammasome activity in AD. And possibly other neurodegenerative diseases associated with inflammation.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:45
Last Modified: 15 Feb 2018 07:45
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/9563

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