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Defining characteristics of Epithelial Ovarian Clear-Cell Cancer and targets for therapy

Caumanns JJ, (2011) Defining characteristics of Epithelial Ovarian Clear-Cell Cancer and targets for therapy. Bachelor's Thesis, Biology.

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Abstract

Ovarian clear-cell carcinomas (OCCC) accounts for 10% of the epithelial ovarian cancers, a cancer type with a high mortality rate worldwide. OCCC development is linked to endometriosis which is the growth of endometrial tissue outside the uterine cavity, what can originate from iron induced oxidative stress. In this study the characteristics, mainly based on genetic studies, of OCCC are identified and possible targets for targeted therapy are discussed. This cancer type consists of only 2 cell types, clear-cells and hobnail cells that contain much glycogen. OCCC is slowly growing and very resistant to chemotherapy. Although a number of mutated genes are commonly found in OCCC, the gene p53 is not mutated. The gene profile of this cancer type consists of more than 50 mutated genes, from which ARID1A, PP2A, HNF-1β, Emi1 and PI3K are specifically mutated in this disease and extensively researched in the last few years. A multidrug therapy designed from targets of these genes together with chemo and operative therapy would provide the best treatment. However, there is more research needed before these genes can be indicated as good targets. Finally the set of 5 specifically mutated genes can be used as biomarkers to identify OCCC in patients.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:46
Last Modified: 15 Feb 2018 07:46
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/9703

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