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The cerebrovascular myogenic response: Defects of the myogenic response in cerebrovascular disease and therapeutic modulation of the myogenic tone.

Bokern, K.A. (2011) The cerebrovascular myogenic response: Defects of the myogenic response in cerebrovascular disease and therapeutic modulation of the myogenic tone. Bachelor's Thesis, Biology.

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Abstract

The myogenic response is the reaction of small arteries and arterioles to changes in intraluminal pressure. By constricting when pressure rises and dilating when pressure drops the blood flow through the organs is kept constant. The vasculature of the brain also shows the myogenic response. This thesis deals with several questions related to the cerebral myogenic response. These questions are answered in six chapters. First, an overview is given of the general myogenic response including its function, its influence on hemodynamics and its independence of the neurohumoral regulatory mechanisms. Second, the cellular mechanisms of the myogenic response are discussed. Several hypotheses on mechanosensation are given and the further molecular signalling pathways leading to the activation of contractile proteins are explained. Third, the cerebral myogenic response is characterized and compared with the general principle. It is discussed whether the endothelium might play a role in the myogenic response, which would be unique to the cerebral vasculature. Fourth, cerebrovascular diseases are described that might be caused by defects of the cerebral myogenic response. These are ischemia/reperfusion injury, cerebral vasospasm after subarachnoid haemorrhage, eclampsia and stroke development. Fifth, potential targets for therapeutic modulation of the general and the cerebral myogenic response are identified such as mediators of mechanosensation, BKCa channels and the RhoA/Rho-kinase pathway. Finally, therapeutic modulation of the cerebral myogenic response is proposed for the medical conditions mentioned in chapter four. This could be done either by administration of drugs targeting the molecular mechanisms that modulate the cerebral myogenic tone or by treatment of defects of the cerebral myogenic response.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:46
Last Modified: 15 Feb 2018 07:46
URI: http://fse.studenttheses.ub.rug.nl/id/eprint/9797

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