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The role of BDNF in energy metabolism

Genne, M.K. van (2012) The role of BDNF in energy metabolism. Bachelor's Thesis, Biology.

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Obesity is rapidly becoming a great problem for western societies. A possible target for treatment may be found in the BDNF system. BDNF affects energy balance by altering both energy intake and energy expenditure. Energy intake is decreased by hypothalamic BDNF administration, by diminishing food intake through hypothalamic mechanisms. The craving for high fat meals is also diminished by acting on the dopaminergic system. In addition, energy expenditure is elevated following hypothalamic BDNF administration or overexpression, partly by increasing locomotion, and partly by increasing the RMR by increasing thermogenesis. Locomotion may be affected by BDNF via an increase of CRH expression, while alteration of thermogenesis may be due to affecting sympathetic nervous system output in BAT. A phenotypic switch of WAT to BAT has been linked to BDNF, but underlying mechanisms are unclear. Most of these effects are mediated via CRH, and glucocorticoid receptors inhibit the release of CRH by BDNF. This review theorizes GRs offer a braking mechanism on BDNFs action.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:48
Last Modified: 15 Feb 2018 07:48

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