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Spatial control of Z ring formation by the Min system in Escherichia coli

Zwarthoff, S.A. (2012) Spatial control of Z ring formation by the Min system in Escherichia coli. Bachelor's Thesis, Biology.

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Bacterial cell division is carried out by the divisome, a multi-protein complex that assembles at the site of division. The first step in the assembly of this complex is the formation of a Z ring at the prospective division site. In rod-shaped bacteria the Z ring is always precisely positioned in the middle of the cell. In Escherichia coli this is accomplished by both nucleoid occlusion and the Min system that consists of the three proteins MinC, MinD and MinE. The Min system has been extensively studied in the past few years and the mechanisms behind the actions of the Min proteins have been elucidated a lot. By determining Min protein structures and performing mutagenesis studies many previously unknown binding sites could be revealed, giving new insights on the interactions and dynamics of the system. However, the exact molecular mechanisms behind the functioning of the Min proteins are still not fully understood. This thesis gives a detailed and updated overview of the interactions between the Min proteins by describing the latest findings on the system and how these findings change the existing models and mechanisms.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:49
Last Modified: 15 Feb 2018 07:49

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