The GxxxG motif and its relation to the dimerization of α-helical transmembrane proteins

Gaastra, BF (2012) The GxxxG motif and its relation to the dimerization of α-helical transmembrane proteins. Bachelor's Thesis, Biology.

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Abstract

Membrane proteins are broadly represented in the genomes of all organisms and serve as the gates between the inside and outside of the cells. Because only a limited amount of high resolution structures are available, studying these proteins is more challenging. This paper presents an overview of the research on the GxxxG motif that is found on the interface of helix-helix interactions inside the membrane. Most of this research has been performed with Glycophorin A as a model peptide. Through multiple mutational studies more data became available on the importance of the GxxxG motif. Later studies also confirmed that this motif is also present on interfaces of helix-helix interactions in water soluble proteins. The GxxxG motif proves to be a powerful motif to predict helix-helix interactions, though it is not sufficient or necessary for dimerization itself.

Item Type:	Thesis (Bachelor's Thesis)
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	15 Feb 2018 07:50
Last Modified:	15 Feb 2018 07:50
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/10414

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