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The role of Collagen type VI in fibrosis

Misrielal, P (2012) The role of Collagen type VI in fibrosis. Bachelor's Thesis, Biology.

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In this review, collagen type VI structure and function are described and its role in fibrosis. Collagen type VI is an extracellular matrix (ECM) component. This protein forms a microfibrillar network in most connective tissues, where it is mostly found. Type VI collagen is produced mainly by fibroblasts, but also by macrophages. The structure of collagen type VI is complex. Collagen VI consist of three α chains, and recently three novel α chains are added. The assembly of this collagen type is a complex process. The three chains, α1, α2 and α3, form a triple helical monomer followed by assembly into disulfide bonded antiparallel dimers. These dimers align to form tetramers that are also stabilized by the disulfide bonds. In the last step, the tetramers are secreted into the ECM forming long molecular chains, known as microfibrils. The function of type VI collagen is not been identified clearly. Studies have shown that collagen VI interacts with several extracellular matrix proteins. Also is indicated that collagen VI anchors large interstitial structures and it has a critical role in integrity of tissues. Collagen VI is expressed in many tissues especially is the muscles. Mutations of the collagen VI genes cause two myopathies, Bethlem myopathy and Ullrich congenital muscular dystrophy. Collagen type VI has an important role in the remodeling of extra cellular matrix and also in several tissues fibrosis. At present, it is known that collagen VI has a role in liver, lung, cardiac and renal fibrosis. It is showed that collagen type VI can be used as a biomarker for liver fibrosis, a non-invasive method. Future studies are required for determination of the role of collagen VI in fibrosis of other tissues and for understanding the mechanism behind this.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:50
Last Modified: 15 Feb 2018 07:50

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