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Towards a Cross-Protective Influenza A Vaccine

Bruggen, J.A.C. van (2012) Towards a Cross-Protective Influenza A Vaccine. Bachelor's Thesis, Biology.

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The threat of a future influenza A pandemic necessitates the development of a vaccine eliciting a cross-protective immune response to influenza A. While several antibodies showing cross-reactive properties to different influenza A subtypes have been identified, the essential and at the same time the most difficult part remains to stimulate the immune system in such a way that its primary response will be the production of such cross-reactive antibodies. This process is especially hindered by the mechanisms in which influenza evolves and causes influenza to evade the immune system. It appears that most cross-reactive antibodies bind to the stem region of hemagglutinin, as it is also noticed in the elderly showing cross-protection to the 1918 H1N1 influenza subtype and the H1N1 pandemic virus which emerged in 2009. In this review article it is revealed that prime-boost immunization fulfills these criteria and could be a possible candidate for the next generation of vaccines.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:51
Last Modified: 15 Feb 2018 07:51

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