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Research Report 1 : A possible role for Vanin in the immunity and ageing of Drosophila Melanogaster

Ashoti, A.R.O. (2013) Research Report 1 : A possible role for Vanin in the immunity and ageing of Drosophila Melanogaster. Master's Thesis / Essay, Biology.

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The well-conserved Vanin family, which can be found in mice, humans and Drosophila Melanogaster, has already proven to play an important role in mice immunity, oxidative injury and inflammation. Vanin encodes an epithelial ectoenzyme with pantetheinase activity, which can generate cysteamine through the metabolism of pantothenic acid. Cysteamine is known to have an inhibitory effect on the production of reduced glutahione (GSH), a major cellular anti-oxidant. Vanin also inhibits the anti-inflammatory peroxisome proliferator-activated receptor-γ (PPARγ), making Vanin a pro-inflammatory protein. Although, the precise role of Vanin is not known yet, Vanin might be a pro-oxidant and play a role in immunity. This report focuses on the role of Vanin in Drosophila Melanogaster, more specifically on Drosophila’s immunity and ageing. Based on observations made by downregulating Vanin in vivo and overexpressing Vanin in vitro, and the effect it had on the immune response and ageing process of Drosophila, we report here that Vanin does play a role in Drosophila immunity and possibly in ageing.

Item Type: Thesis (Master's Thesis / Essay)
Degree programme: Biology
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 15 Feb 2018 07:52
Last Modified: 15 Feb 2018 07:52

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