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Cre LoxP Mouse Models

Manning, F. (2013) Cre LoxP Mouse Models. Bachelor's Thesis, Biology.

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Cancer is a growing problem because the average lifespan increases which raises the change to develop cancer. Due to medical limitations a lot of people die because of this disease. Ovarian cancer is a type of cancer with very poor prognosis due to the lack of understanding the etiology and few medical options. The biggest problem of chemotherapy nowadays is that they destroy almost the complete tumor but a few cells still survive resulting in resistance against the chemotherapy. A lot of methods have been used so far to study the onset and progression of ovarian cancer because there are many different subtypes. A method that mimics natural conditions of gene knockouts very closely is the Cre loxP system. It is a method to silence or activate genes of interest in only specific tissues. The use of Cre loxP in ovarian cancer has only started recently after it was proven to be very successful in the research of breast cancer. With this system it is possible to monitor the influence of certain gene knockouts or pathways. This thesis focuses on different mouse models that have been produced so far with Cre loxP in the research of ovarian cancer.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:52
Last Modified: 15 Feb 2018 07:52

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