The Role of the Tumour Microenvironment on the development of Medulloblastoma

Linnemann, J.E.M. (2013) The Role of the Tumour Microenvironment on the development of Medulloblastoma. Bachelor's Thesis, Biology.

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Abstract

A lot is already known about several genetic mutations that play a role in the nascence of cancer. However a lot is still unknown about the possibility of the involvement of microenvironmental factors in the development of cancer. This review therefore focuses on the factors in the tumour microenvironment which are already known and link these to Medulloblastoma, since a lot is still unknown about this specific type of cancer and since it still remains the most malignant type of tumour in infants and young children. This review will focus on the role of the immune system; tumour associated macrophages, myeloid derived suppressor cells, epithelial-to-mesenchymal transition, cancer associated fibroblasts, hypoxia, oxidative stress, Wnt, SHH, Notch, BMP, TGF-β and NMDAR. All of the above mentioned factors are individually involved in the development of cancer and tumour progression all contributing to one of the multiple mechanisms of cancer metastasis and tumour progression. Some of these factors overlap with the development of Medulloblastoma, especially some cells of the immune system, the Wnt and SHH pathways and TGF-β. This overlap emphasizes the importance of these factors and indicating a synergic effect of these factors. This is because the development of tumours never depends on one single factor. Furthermore, these factors could in the future lead to specific targets for new therapeutic treatments of cancer.

Item Type:	Thesis (Bachelor's Thesis)
Degree programme:	Biology
Thesis type:	Bachelor's Thesis
Language:	English
Date Deposited:	15 Feb 2018 07:53
Last Modified:	15 Feb 2018 07:53
URI:	https://fse.studenttheses.ub.rug.nl/id/eprint/11034

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