Huckriede, B. F. (2013) The effects of abdominal surgery on post operative cognitive dysfunction. Master's Thesis / Essay, Biology.
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Abstract
Post operative cognitive dysfunction is a disorder which affects learning and memory after surgery and can persist for long periods of time. Due to aging and high number of performed surgeries it primarily affects the elderly and their quality of life after treatments. The aim of this study was to analyse the effects of abdominal surgery on learning and memory in three month old wistar rats. Although POCD has long term clinical effects this study only aimed to analyse the animals' performance in the short term, up until three weeks after surgery. The animals' performance was assessed by using behavioural tests aimed at learning, memory and attention. Results showed no effects of anaesthesia on cognitive function but did show a decrease in learning and memory in treated animals that lasted up to two weeks. Treated groups also showed a decrease in spatial memory that lasted up to two weeks. Because POCD is a characterized as a long term dysfunction it would be expected that cognition would be impaired for longer periods of time. This however was not found.
| Item Type: | Thesis (Master's Thesis / Essay) |
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| Degree programme: | Biology |
| Thesis type: | Master's Thesis / Essay |
| Language: | English |
| Date Deposited: | 15 Feb 2018 07:53 |
| Last Modified: | 15 Feb 2018 07:53 |
| URI: | https://fse.studenttheses.ub.rug.nl/id/eprint/11194 |
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