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The evolution and prevention of Antibiotic resistance in Human pathogens

Oomen, M.E. (2013) The evolution and prevention of Antibiotic resistance in Human pathogens. Bachelor's Thesis, Biology.

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Antibiotic resistance is a big problem worldwide. If we do not learn how to prevent resistance from occurring, we might go back to the times before the discovery of antibiotics. However, the more is known about the evolution of antibiotic resistance in pathogens, the more difficult it seems to prevent it. Antibiotic resistance is not new since the discovery of penicillin, however the spread is new. Antibiotic resistance is spreading rapidly, because most genes, which acquire resistance, are located at mobile elements. Therefore bacteria can pass it on easily via horizontal gene transfer to cells in their environment. Because a lot of cells are exposed to concentrations of antibiotic, by therapeutically use in humans, but also in agriculture and animal farming, the evolutionary pressure is high. This makes that the resistance cells have a big advantage and makes them spread easily in pathogens and in non-pathogenic cells. Nowadays resistant cells are all around us and it is inevitable that there will be resistance in pathogens for each antibiotic if it is biochemically possible. It is still guessing how to prevent this, however it is most likely that the answer lies in altering the dose, the combination and the structures of the antibiotics we use.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:53
Last Modified: 15 Feb 2018 07:53

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