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Essay: It all comes together... at the APB

Schippers, L.M. (2013) Essay: It all comes together... at the APB. Master's Thesis / Essay, Biology.

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In order to proliferate indefinitely, cancer cells and immortalized cell lines maintain their telomeres with either telomerase or an alternative lengthening of telomeres (ALT) mechanism, which relies on homologous recombination-mediated extension of telomeres. One of the hallmarks of ALT is the presence of ALT-associated promyelocytic leukemia (PML) bodies (APBs). APBs are likely to function as a scaffold which brings telomeres and DNA repair and recombination factors together, and are therefore thought to play an important role in facilitating homologous recombination at telomeres. However, the molecular details of this mechanism are largely unknown. This review will focus on the formation and function of APBs, and the putative roles for chromatin state and two novel proteins (TAH1 and β-TrCP1) will be discussed. In addition, I will discuss some ideas about remaining questions and possible experiments. The mechanisms by which telomeres are maintained via ALT! are complicated, but understanding the role of APBs is a major piece in the puzzle. Ultimately, unraveling these ALT mechanisms will be a huge step forward in the development of ALT-specific cancer therapies.

Item Type: Thesis (Master's Thesis / Essay)
Degree programme: Biology
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 15 Feb 2018 07:54
Last Modified: 15 Feb 2018 07:54

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