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Finding an animal model of schizophrenia: Combining induction strategies to create new research opportunities.

Knop, J. (2013) Finding an animal model of schizophrenia: Combining induction strategies to create new research opportunities. Bachelor's Thesis, Biology.

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For many years, animal models are of great importance for biological and pharmacological research. They help in revealing novel information about disease and provide assistance in developing treatment strategies. However, treatment of the neurodevelopmental disorder schizophrenia is still insufficient, mainly because the underlying biology of this devastating disorder is largely unknown. Because of the complexity of onset and development of schizophrenia, creating an animal model possessing all the characteristics is extremely hard, or even impossible. In this thesis the criteria of an animal of schizophrenia and the different methods of creating such an animal model are discussed. It is important to generate an animal model that matches the frequently proposed two (third) hit hypothesis of schizophrenia, stating that a series of stressfull events to a genetically vulnerable individual leads to the development and onset of schizophrenia. To create an animal model that mimics this neuropathology best, combinations of induction strategies should be tested for face, construct and predictive validity, ultimately resulting in an animal model possessing as many of the characteristics of schizophrenia as possible. Recent results reveal that inbred Roman High Avoidance and Roman Low Avoidance rats possess promising characteristics and should therefor be further tested for suitability in schizophrenic research. Combined with a proper feedback cycle from clinical findings this can lead to a valuable animal model generating better understanding and development of preventative strategies for schizophrenia.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:54
Last Modified: 15 Feb 2018 07:54

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