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Essay : Is there an interaction between Wnt and cAMP signaling in cell proliferation?

Muis, J. (2013) Essay : Is there an interaction between Wnt and cAMP signaling in cell proliferation? Master's Thesis / Essay, Biology.

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The Wnt and cAMP signaling pathways are both known to stimulate cell proliferation. The aim of this review was to investigate whether there’s an interaction between these two pathways in cell proliferation. There’s already been a lot of research about the cooperation between cAMP/PKA and Wnt signaling at different levels. The first interaction between these two was PKA phosphorylation of β-catenin which stabilizes β-catenin and stimulates Wnt transcriptional activity. Besides that, PTH and PGE2, both stimulators of cAMP, can induce Wnt signaling at least in part through cAMP/PKA. When it comes to cAMP/Epac and Wnt signaling, there’s not much known in literature. But recently there were some articles published about downstream effectors of Epac interacting with Wnt/β-catenin, for example Rap1 which can induce β-catenin mediated transcription. Next to that, also PLD can be stimulated by β-catenin mediated transcription and PLD can activate Wnt/β-catenin via a positive feedback loop. The Wnt pathway also interacts with H-Ras; when Wnt signaling is inactive, the destruction complex can bind to H-Ras and degrade it. In this way, it regulates the effect of Epac/H-Ras on cell proliferation. Finally, the ERK pathway can be stimulated by both PKA and Epac and this pathway is very important for cell proliferation. Two Wnt proteins, Axin and APC, can reduce β-catenin levels and this result in decrease dRas protein levels and ERK pathway components. So when β-catenin is stabilized by Wnt signaling, Ras protein levels and ERK pathway components are upregulated and can induce (tumorigenic) cell proliferation. This review summarizes the connections between cAMP and Wnt signaling that are known in literature now.

Item Type: Thesis (Master's Thesis / Essay)
Degree programme: Biology
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 15 Feb 2018 07:54
Last Modified: 15 Feb 2018 07:54

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