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Effects of acylated and unacylated ghrelin on lipid metabolism

Kosse M.J. (2013) Effects of acylated and unacylated ghrelin on lipid metabolism. Bachelor's Thesis, Biology.

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The “hunger hormone” ghrelin is one of the hormones that is known to influence energy regulation and therefore potential target to fight obesity. Ghrelin occurs in different forms. The two major forms known are acylated ghrelin (AG) and unacylated ghrelin (UAG). Moreover, for a long time UAG is seen as the inactive form of ghrelin, while nowadays experiments show that it is an active protein with it own and possibly antagonizing effects on AG. The aim of the present study is to give an overview of the effects of AG and UAG on the lipid metabolism. AG elevates the food-intake, inguinal and retroperitoneal white adipose tissue volumes and the activity of genes involved in lipid uptake and lipogenesis. UAG decreases food-intake, epididymal and perianal white adipose tissue volumes and suppresses genes that encode for regulatory enzymes involved in adipogenesis, lipogenesis and sterol synthesis in white adipose tissue. In conclusion, both AG and UAG have influence on the lipid metabolism of individuals. It was thought that UAG had antagonizing effects on AG. In certain perspectives this agrees with studies about AG and UAG, but there is no consensus in current literture. In future experiments UAG needs to be further investigated. Furthermore, it is important to make a clear difference between AG and UAG in experiments and literature.

Item Type: Thesis (Bachelor's Thesis)
Degree programme: Biology
Thesis type: Bachelor's Thesis
Language: English
Date Deposited: 15 Feb 2018 07:55
Last Modified: 15 Feb 2018 07:55

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