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Essay : The role of LRRK2 in Parkinson’s disease

Razquin Navas, P. (2013) Essay : The role of LRRK2 in Parkinson’s disease. Master's Thesis / Essay, Biology.

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Parkinson's disease (PD) is the second most prevalent neurodegenerative diseasejust behind Alzheimer. It is a progressive disorder of the nervous system that affects movement. Although it was believed to be a sporadic pathology triggered by environmental factors, nowadays a lot of PD-related genes have been identified, including LRRK2. Mutations in LRRK2 are a major genetic risk factor for both familial and sporadic PD, being present in 4% cases of familial and 1% cases of sporadic disease. However, the pathway by which LRRK2 drives to PD development is still unknown. Multiple pathways have been linked with LRRK2 such as autophagy, inflammation, synapsis, apoptosis, cytoskeleton interaction and mitochondria homeostasis. In this essay, these pathways and the evidences found to date of LRRK2 playing a key role in them are described. In brief, this protein could have multiple roles because it is a big protein with two enzymatic domains and multiple protein-protein interaction domains. However, due to the strong association found between LRRK2, tau and α –synuclein and the location of LRRK2 in microtubules and membranes, I consider that the hyperphosphorylation of tau within the microtubules is the hypothesis that better brings together all the findings discovered to date and, therefore, the study of this interaction should be the future direction of research.

Item Type: Thesis (Master's Thesis / Essay)
Degree programme: Biology
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 15 Feb 2018 07:55
Last Modified: 15 Feb 2018 07:55

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