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Essay: TREM-2 expressing microglia in neurodegeneration

Chiang, C. (2013) Essay: TREM-2 expressing microglia in neurodegeneration. Master's Thesis / Essay, Biology.

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At present, it is still unclear how the innate immune response relates to several neuroinflammatory and neurodegenerative diseases such as Multiple sclerosis (MS) and Alzheimer’s diseases (AD). Genome-wide association studies have revealed several genes and/or mutations which correlate with the risk for neurodegeneration. One receptor found to be involved, is the in 2000 discovered triggering receptor expressed on myeloid cells-2 (TREM-2). The receptor is expressed by microglia in the central nervous system (CNS) and TREM-2 expressing microglia function as phagocytic cells to clear neuronal debris, and can initiate an anti-inflammatory response. Furthermore, TREM-2 seems to be involved in neurodegeneration since loss-of function mutation TREM-2 found to causes the chronic neurodegenerative disease, Nasu-Hakola. Recent, researchers have found mutation in AD patients which was correlated with the risk to develop Alzheimer’s disease. Both, in AD and in MS, high expression of TREM-2 was found on activated microglia. In this essay, the role of TREM-2 on microglia in Alzheimer’s diseases and Multiple Sclerosis is discussed.

Item Type: Thesis (Master's Thesis / Essay)
Degree programme: Biology
Thesis type: Master's Thesis / Essay
Language: English
Date Deposited: 15 Feb 2018 07:55
Last Modified: 15 Feb 2018 07:55

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